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Hypoxia-inducible factor pathway and diseases of the vascular wall

Abstract:

Background: Hypoxia may contribute to the pathogenesis of various diseases of the vascular wall. Hypoxia-inducible factors (HIFs) are nuclear transcriptional factors that regulate the transcription of genes that mediate cellular and tissue homeostatic responses to altered oxygenation. This article reviews the published literature on and discusses the role of the HIF pathway in diseases involving the vascular wall, including atherosclerosis, arterial aneurysms, pulmonary hypertension, vascular...

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Publisher copy:
10.1016/j.jvs.2013.02.240

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Sandison, A More by this author
Paleolog, EM More by this author
Davies, AH More by this author
Journal:
Journal of Vascular Surgery
Volume:
58
Issue:
1
Pages:
219-230
Publication date:
2013-07-05
DOI:
EISSN:
1097-6809
ISSN:
0741-5214
URN:
uuid:c8895106-61e8-4904-9eb3-fb0b8abb0c98
Source identifiers:
411509
Local pid:
pubs:411509
Language:
English

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