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Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of oseltamivir and its metabolite oseltamivir carboxylate in plasma, saliva and urine.

Abstract:

A bioanalytical method for the analysis of oseltamivir (OP) and its metabolite oseltamivir carboxylate (OC) in human plasma, saliva and urine using off-line solid-phase extraction and liquid chromatography coupled to positive tandem mass spectroscopy has been developed and validated. OP and OC were analysed on a ZIC-HILIC column (50 mm x 2.1 mm) using a mobile phase gradient containing acetonitrile-ammonium acetate buffer (pH 3.5; 10mM) at a flow rate of 500 microL/min. The method was validat...

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Publication status:
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Authors


Lindegårdh, N More by this author
Hanpithakpong, W More by this author
Wattanagoon, Y More by this author
Singhasivanon, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Journal:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Volume:
859
Issue:
1
Pages:
74-83
Publication date:
2007-11-05
DOI:
EISSN:
1873-376X
ISSN:
1570-0232
URN:
uuid:c87e2e00-6d67-49b7-8d30-a48e2d42f8f2
Source identifiers:
25761
Local pid:
pubs:25761

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