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Journal article

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates.

Abstract:

The complement system is an essential component of the innate and acquired immune system, and consists of a series of proteolytic cascades that are initiated by the presence of microorganisms. In health, activation of complement is precisely controlled through membrane-bound and soluble plasma-regulatory proteins including complement factor H (fH; ref. 2), a 155 kDa protein composed of 20 domains (termed complement control protein repeats). Many pathogens have evolved the ability to avoid imm...

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Publication status:
Published

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Publisher copy:
10.1038/nature07769

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Journal:
Nature
Volume:
458
Issue:
7240
Pages:
890-893
Publication date:
2009-04-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:c8754af6-8838-403f-bcd0-ba837f6ccc71
Source identifiers:
15743
Local pid:
pubs:15743

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