Journal article
Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria.
- Abstract:
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Severe Plasmodium falciparum malaria is a major cause of global mortality, yet the immunological factors underlying progression to severe disease remain unclear. CD4(+)CD25(+) regulatory T cells (Treg cells) are associated with impaired T cell control of Plasmodium spp infection. We investigated the relationship between Treg cells, parasite biomass, and P. falciparum malaria disease severity in adults living in a malaria-endemic region of Indonesia. CD4(+)CD25(+)Foxp3(+)CD127(lo) Treg cells w...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 624.1KB)
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- Publisher copy:
- 10.1371/journal.ppat.1000402
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Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS pathogens Journal website
- Volume:
- 5
- Issue:
- 4
- Pages:
- e1000402
- Publication date:
- 2009-04-01
- DOI:
- EISSN:
-
1553-7374
- ISSN:
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1553-7366
- Source identifiers:
-
61493
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:c8744fb7-ceb9-49e8-a29e-9126f1ab050a
- Local pid:
- pubs:61493
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Minigo et al
- Copyright date:
- 2009
- Notes:
- © 2009 Minigo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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