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Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria.

Abstract:

Severe Plasmodium falciparum malaria is a major cause of global mortality, yet the immunological factors underlying progression to severe disease remain unclear. CD4(+)CD25(+) regulatory T cells (Treg cells) are associated with impaired T cell control of Plasmodium spp infection. We investigated the relationship between Treg cells, parasite biomass, and P. falciparum malaria disease severity in adults living in a malaria-endemic region of Indonesia. CD4(+)CD25(+)Foxp3(+)CD127(lo) Treg cells w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1000402

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Funding agency for:
Price, R
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
5
Issue:
4
Pages:
e1000402
Publication date:
2009-04-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
61493
Language:
English
Keywords:
UUID:
uuid:c8744fb7-ceb9-49e8-a29e-9126f1ab050a
Local pid:
pubs:61493
Deposit date:
2012-12-19

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