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Induction of antibody responses in vivo by antigen specific helper factor.

Abstract:

T helper cell factors (HF) have been preparated against protein and synthetic antigens by restimulating in vitro induced helper cells with small amounts of antigen. HF when tested in vitro are antigen specific and capable of replacing T cells, initiating a thymus dependent IgM response. In the in vivo adoptive transfer assay HF is capable of replacing T helper cells and is active at very high dilution, inducing both IgM and IgG responses. When tested on unirradiated DNP primed animals the HF ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Immunobiology
Volume:
156
Issue:
1-2
Pages:
13-24
Publication date:
1979-08-05
EISSN:
1878-3279
ISSN:
0171-2985
URN:
uuid:c8733e51-27b8-4bc5-8ec7-4c933c3f0463
Source identifiers:
481939
Local pid:
pubs:481939

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