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Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

Abstract:

Endogenous damage-associated molecular patterns (DAMPs) are released during tissue damage and have increasingly recognized roles in the etiology of many human diseases. The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD), are immune-mediated conditions where high levels of DAMPs are observed. DAMPs such as calprotectin (S100A8/9) have an established clinical role as a biomarker in IBD. In this review, we use IBD as an archet...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/mi.2016.14

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
Mucosal Immunology Journal website
Volume:
9
Issue:
3
Pages:
567-582
Publication date:
2016-03-02
Acceptance date:
2015-12-31
DOI:
EISSN:
1935-3456
ISSN:
1933-0219
Keywords:
Pubs id:
pubs:905661
UUID:
uuid:c870b49f-a727-41fa-951b-012954f04dd1
Local pid:
pubs:905661
Source identifiers:
905661
Deposit date:
2018-08-14

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