The evolutionary dynamics of influenza A virus adaptation to mammalian hosts.

Journal article

Few questions on infectious disease are more important than understanding how and why avian influenza A viruses successfully emerge in mammalian populations, yet little is known about the rate and nature of the virus' genetic adaptation in new hosts. Here, we measure, for the first time, the genomic rate of adaptive evolution of swine influenza viruses (SwIV) that originated in birds. By using a curated dataset of more than 24 000 human and swine influenza gene sequences, including 41 newly c...

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Authors: Bhatt, S; Lam, T; Lycett, S; Leigh Brown, A; Bowden, T

• Publication status: Published
• Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• Volume: 368
• Issue: 1614
• Pages: 20120382
• Publication date: 2013-03-01
• DOI: 10.1098/rstb.2012.0382
• EISSN: 1471-2970
• ISSN: 0962-8436
• Language: English
• Keywords: Humans; Models, Genetic; Adaptation, Biological; Phylogeny; Swine; Swine Diseases; Host Specificity; Zoonoses; Databases, Genetic; Hemagglutinins, Viral; Influenza A virus; Orthomyxoviridae Infections; Combating Swine Influenza Consortium; Animals; Neuraminidase; Likelihood Functions; Evolution, Molecular