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Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

Abstract:

Functional outcomes of ephrin binding to Eph receptors (Ephs) range from cell repulsion to adhesion. Here we used cell collapse and stripe assays, showing contrasting effects of human ephrinA5 binding to EphA2 and EphA4. Despite equivalent ligand binding affinities, EphA4 triggered greater cell collapse, whereas EphA2-expressing cells adhered better to ephrinA5-coated surfaces. Chimeric receptors showed that the ectodomain is a major determinant of cell response. We report crystal structures ...

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Publisher copy:
10.1038/nsmb.2617

Authors


Journal:
Nature Structural and Molecular Biology More from this journal
Volume:
20
Issue:
8
Pages:
958-964
Publication date:
2013-08-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Pubs id:
pubs:419050
UUID:
uuid:c85d9bed-b1fb-4e84-956f-995eecf31371
Local pid:
pubs:419050
Source identifiers:
419050
Deposit date:
2013-11-17

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