- Abstract:
-
PURPOSE: Anti-vascular endothelial growth factor therapy enhances the activity of radiotherapy in experimental models, and bevacizumab has therapeutic activity in patients with metastatic colorectal cancer. EXPERIMENTAL DESIGN: Twenty-two patients with locally advanced inoperable colorectal carcinomas (LA/I-CRC) were treated with conformal hypofractionated (3.4 Gy/fraction x 15) split-course accelerated radiotherapy (biological equivalent dose, 67.2 Gy) supported with amifostine, capecitabin...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1158/1078-0432.ccr-09-0688
-
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- Journal:
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Volume:
- 15
- Issue:
- 22
- Pages:
- 7069-7076
- Publication date:
- 2009-11-05
- DOI:
- EISSN:
-
1557-3265
- ISSN:
-
1078-0432
- URN:
-
uuid:c85d455c-99cd-4693-a873-b1964c89a05b
- Source identifiers:
-
34957
- Local pid:
- pubs:34957
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab.
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