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Journal article

Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab.

Abstract:

PURPOSE: Anti-vascular endothelial growth factor therapy enhances the activity of radiotherapy in experimental models, and bevacizumab has therapeutic activity in patients with metastatic colorectal cancer. EXPERIMENTAL DESIGN: Twenty-two patients with locally advanced inoperable colorectal carcinomas (LA/I-CRC) were treated with conformal hypofractionated (3.4 Gy/fraction x 15) split-course accelerated radiotherapy (biological equivalent dose, 67.2 Gy) supported with amifostine, capecitabin...

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Publication status:
Published

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Authors


Koukourakis, MI More by this author
Giatromanolaki, A More by this author
Sheldon, H More by this author
Kouklakis, G More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
15
Issue:
22
Pages:
7069-7076
Publication date:
2009-11-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:c85d455c-99cd-4693-a873-b1964c89a05b
Source identifiers:
34957
Local pid:
pubs:34957

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