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Selective IgA deficiency and Crohn's disease: report of two cases.

Abstract:
Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The typical clinical course and histology in these two patients suggest that IgA-mediated responses in the mucosa are not involved in the pathogenesis of Crohn's disease.
Publication status:
Published

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Publisher copy:
10.1136/gut.18.8.644
Journal:
Gut More from this journal
Volume:
18
Issue:
8
Pages:
644-646
Publication date:
1977-08-01
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
Language:
English
Keywords:
Pubs id:
pubs:165788
UUID:
uuid:c84e2209-55f6-4acb-944c-ba900044d08a
Local pid:
pubs:165788
Source identifiers:
165788
Deposit date:
2012-12-19

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