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Glycosylation influences the lectin activities of the macrophage mannose receptor.

Abstract:

The mannose receptor (MR) is a heavily glycosylated endocytic receptor that recognizes both mannosylated and sulfated ligands through its C-type lectin domains and cysteine-rich (CR) domain, respectively. Differential binding properties have been described for MR isolated from different sources, and we hypothesized that this could be due to altered glycosylation. Using MR transductants and purified MR, we demonstrate that glycosylation differentially affects both MR lectin activities. MR tran...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m503457200

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Journal:
Journal of biological chemistry More from this journal
Volume:
280
Issue:
38
Pages:
32811-32820
Publication date:
2005-09-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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