Analysis of peptide-binding motifs for two disease associated HLA-DR13 alleles using an M13 phage display library.

Journal article

Major histocompatibility complex (MHC) molecules bind peptides bearing an appropriate 'sequence motif' for MHC binding. The use of phage display libraries exploits the ability of MHC class II molecules to exchange peptides in solution and thus select out peptide sequences with high-affinity binding from a large array of random peptides. We have analysed the peptide binding motifs of HLA-DRB1*1301 and *1302 using affinity purified HLA-DR13 molecules to purify sequentially HLA-DR13-binding pept...

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Authors: Davenport, M; Quinn, C; Valsasnini, P; Sinigaglia, F; Hill, A

• Publication status: Published
• Journal: Immunology
• Volume: 88
• Issue: 4
• Pages: 482-486
• Publication date: 1996-08-01
• DOI: 10.1046/j.1365-2567.1996.d01-693.x
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Amino Acid Sequence; Hepatitis B; Bacteriophage M13; Alleles; Humans; Peptides; HLA-DR Antigens; Malaria; Molecular Sequence Data