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T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse.

Abstract:

The role of non-muscle myosin IIA (heavy chain encoded by the non-muscle myosin heavy chain 9 gene, Myh9) in immunological synapse formation is controversial. We have addressed the role of myosin IIA heavy chain protein (MYH9) in mouse T cells responding to MHC-peptide complexes and ICAM-1 in supported planar bilayers - a model for immunological synapse maturation. We found that reduction of MYH9 expression levels using Myh9 siRNA in proliferating mouse CD4(+) AND T cell receptor (TCR) transg...

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Publisher copy:
10.3389/fimmu.2012.00230

Authors


Vardhana, S More by this author
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Journal:
Frontiers in immunology
Volume:
3
Issue:
AUG
Pages:
230
Publication date:
2012
DOI:
EISSN:
1664-3224
URN:
uuid:c8466ac2-70a8-43ee-810e-1542ce9b46da
Source identifiers:
426245
Local pid:
pubs:426245

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