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Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.

Abstract:

Genome-wide association studies (GWAS), although efficient to detect genes involved in complex diseases, are not designed to measure the real effect of the genes. This is illustrated here by the example of IL2RA in multiple sclerosis (MS). Association between IL2RA and MS is clearly established, although the functional variation is still unknown: the effect of IL2RA might be better described by several SNPs than by a single one. This study investigates whether a pair of SNPs better explains t...

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Publication status:
Published

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Publisher copy:
10.1038/ejhg.2011.197

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
European journal of human genetics : EJHG More from this journal
Volume:
20
Issue:
3
Pages:
321-325
Publication date:
2012-03-01
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Language:
English
Keywords:
Pubs id:
pubs:206049
UUID:
uuid:c842bce1-5d1d-4adf-8580-ba5e80829f98
Local pid:
pubs:206049
Source identifiers:
206049
Deposit date:
2012-12-19

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