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Thesis

The role of CCL25 and CCR9 in intestinal inflammation

Abstract:

Leukocyte extravasation is mediated in part by tissue specific chemotactic cytokines (chemokines) and specific chemokine receptors expressed on the surface of circulating cells. C-C chemokine ligand CCL25 is expressed exclusively in the intestine and thymus and mediates chemotaxis by cells expressing receptor CCR9. This chemokine and receptor pair may be relevant in the pathogenesis of intestinal inflammation, in diseases such as Crohn’s disease (CD) and coeliac disease. In this thesis ...

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Institution:
University of Oxford
Oxford college:
Magdalen College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author

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Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:c8413dcb-4861-4afd-ae13-5cb88935e54d
Local pid:
ora:7325

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