The diagnosis and management of malignant phaeochromocytoma and paraganglioma.

Journal article

Malignant phaeochromocytomas are rare tumours accounting for ~10% of all phaeochromocytomas; the prevalence of malignancy among paragangliomas is higher, especially those associated with succinate dehydrogenase subunit B gene mutations. Although a subset of these tumours has metastatic disease at initial presentation, a significant number develops metastases during follow-up after excision of an apparently benign tumour. Clinical, biochemical and histological features cannot reliably distingu...

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Authors: Chrisoulidou, A; Kaltsas, G; Ilias, I; Grossman, AB

• Publication status: Published
• Journal: Endocrine-related cancer
• Volume: 14
• Issue: 3
• Pages: 569-585
• Publication date: 2007-09-01
• DOI: 10.1677/erc-07-0074
• EISSN: 1479-6821
• ISSN: 1351-0088
• Language: English
• Keywords: Endocrine Surgical Procedures; Antineoplastic Combined Chemotherapy Protocols; Adrenal Gland Neoplasms; Algorithms; Humans; Combined Modality Therapy; Radiotherapy; Pheochromocytoma; Tumor Markers, Biological; Paraganglioma; Radiopharmaceuticals; Chromaffin Cells