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Journal article

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration

Abstract:: enofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-containing first-line regimen. However, the full spectrum of reverse transcriptase (RT) mutations selected in individuals with VF on such a regimen is not known. To identify TDF regimen-associated mutations (TRAMs), we compared the proportion of each RT mutation in 2873 individuals with VF on a WHO-recommended firs...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Rhee, S., Varghese, V., Holmes, S., Van Zyl, G., Steegen, K., Boyd, M., Cooper, D., Nsanzimana, S., Saravanan, S., Charpentier, C., de Oliveira, T., Etiebet, M., Garcia, F., Goedhals, D., Gomes, P., Günthard, H., Hamers, R., Hoffmann, C., Hunt, G., … Shafer, R. (2017). Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration. EBioMedicine, 18, 225–235.

MLA Style

Rhee, S., et al. “Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.” EBioMedicine, vol. 18, Elsevier, 2017, pp. 225–35.

Chicago Style

Rhee, S, V Varghese, S Holmes, G Van Zyl, K Steegen, M Boyd, D Cooper, et al. 2017. “Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.” EBioMedicine 18: 225–35.
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Files:: Soo-Yon Rhee mutations...

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Publisher copy:: 10.1016/j.ebiom.2017.03.024

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+ Rhee, S More by this author

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+ Varghese, V More by this author

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+ Holmes, S More by this author

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+ Van Zyl, G More by this author

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+ Steegen, K More by this author

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Funding

+ National Institute of Allergy and Infectious Diseases More from this funder

Grant:

U01AI068636

Bibliographic Details

Publisher:: Elsevier Publisher's website
Journal:: EBioMedicine Journal website
Volume:: 18
Pages:: 225-235
Publication date:: 2017-04-01
Acceptance date:: 2017-03-17
DOI:: 10.1016/j.ebiom.2017.03.024
EISSN:: 2352-3964
ISSN:: 2352-3964

Item Description

Keywords:: Journal Article
Pubs id:: pubs:699704
UUID:: uuid:c83a4759-2c68-4bdd-9a78-37a0ae72ab07
Local pid:: pubs:699704
Source identifiers:: 699704
Deposit date:: 2017-06-14

Terms of use

Copyright holder:: Rhee et al
Copyright date:: 2017
Notes:: © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.

Licence:: CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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