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Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome.

Abstract:

Here, we report the successful design, construction, and characterization of a 770-kilobase synthetic yeast chromosome II (synII). Our study incorporates characterization at multiple levels-including phenomics, transcriptomics, proteomics, chromosome segregation, and replication analysis-to provide a thorough and comprehensive analysis of a synthetic chromosome. Our Trans-Omics analyses reveal a modest but potentially relevant pervasive up-regulation of translational machinery observed in syn...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1126/science.aaf4791

Authors


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Funding agency for:
Richardson, SM
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Funding agency for:
Marston, AL
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
355
Issue:
6329
Pages:
1-11
Publication date:
2017-03-10
Acceptance date:
2017-02-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pubs id:
pubs:685491
URN:
uri:c82ec7eb-3254-476b-96d1-7c685ac3ea93
UUID:
uuid:c82ec7eb-3254-476b-96d1-7c685ac3ea93
Local pid:
pubs:685491
Language:
English
Keywords:

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