Congenital toxoplasmosis: continued parasite proliferation in the fetal brain despite maternal immunological control in other tissues.

Journal article

BACKGROUND: Congenital toxoplasmosis is a serious condition but little is known of the natural history of parasite development and associated fetal tissue destruction. METHODS: Two cases identified by ultrasound underwent induced abortion at 21 and 30 weeks' gestation. At autopsy, the placenta and fetal organs were examined by histology and immunocytochemistry employing anti-Toxoplasma stage-specific antibodies to confirm diagnosis and also provide information on the stage of parasite develo...

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Authors: Ferguson, D; Bowker, C; Jeffery, K; Chamberlain, P; Squier, W

• Publication status: Published
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Volume: 56
• Issue: 2
• Pages: 204-208
• Publication date: 2013-01-01
• DOI: 10.1093/cid/cis882
• EISSN: 1537-6591
• ISSN: 1058-4838
• Language: English
• Keywords: Prenatal Diagnosis; Pregnancy; Humans; Adult; Immunoglobulin G; Toxoplasmosis, Congenital; Female; Placenta; Brain; Antibodies, Protozoan; Immunoglobulin M; Fetal Diseases; Toxoplasma; Biopsy