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An analytical method for disentangling the roles of adhesion and crowding for random walk models on a crowded lattice

Abstract:
Migration of cells and molecules in vivo is affected by interactions with obstacles. These interactions can include crowding effects, as well as adhesion/repulsion between the motile cell/molecule and the obstacles. Here we present an analytical framework that can be used to separately quantify the roles of crowding and adhesion/repulsion using a lattice-based random walk model. Our method leads to an exact calculation of the long time Fickian diffusivity, and avoids the need for computationally expensive stochastic simulations.
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Oxford college:
St Hugh's College
Role:
Author
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Name:
Australian Research Council
Grant:
FT130100148
Publisher:
Institute of Physics
Journal:
Physical Biology More from this journal
Volume:
13
Issue:
5
Publication date:
2016-09-01
Acceptance date:
2016-08-24
DOI:
EISSN:
1478-3975
ISSN:
1478-3967
Keywords:
Pubs id:
pubs:661051
UUID:
uuid:c81cb8f8-20d2-4df4-8b06-e39ec205e9fd
Local pid:
pubs:661051
Source identifiers:
661051
Deposit date:
2016-12-01

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