Journal article
Effects of intracellular pH on ATP-sensitive K+ channels in mouse pancreatic beta-cells.
- Abstract:
-
1. The effects of intracellular pH (pHi) on the ATP-sensitive K+ channel (K+ATP channel) from mouse pancreatic beta-cells were examined in inside-out patches exposed to symmetrical 140 mM K+ solutions. 2. The relationship between channel activity and pHi was described by the Hill equation with half-maximal inhibition (Ki) at pHi 6.25 and a Hill coefficient of 3.7. 3. Following exposure to pHi < 6.8, channel activity did not recover to its original level. Subsequent application of trypsin t...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of physiology
- Volume:
- 475
- Issue:
- 1
- Pages:
- 33-44
- Publication date:
- 1994-02-01
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- Source identifiers:
-
114035
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:114035
- UUID:
-
uuid:c814fa51-05b1-4e4e-9a6e-712b420ea228
- Local pid:
- pubs:114035
- Deposit date:
- 2012-12-19
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- Copyright date:
- 1994
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