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Journal article

Effects of intracellular pH on ATP-sensitive K+ channels in mouse pancreatic beta-cells.

Abstract:

1. The effects of intracellular pH (pHi) on the ATP-sensitive K+ channel (K+ATP channel) from mouse pancreatic beta-cells were examined in inside-out patches exposed to symmetrical 140 mM K+ solutions. 2. The relationship between channel activity and pHi was described by the Hill equation with half-maximal inhibition (Ki) at pHi 6.25 and a Hill coefficient of 3.7. 3. Following exposure to pHi < 6.8, channel activity did not recover to its original level. Subsequent application of trypsin t...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of physiology
Volume:
475
Issue:
1
Pages:
33-44
Publication date:
1994-02-01
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
114035
Language:
English
Keywords:
Pubs id:
pubs:114035
UUID:
uuid:c814fa51-05b1-4e4e-9a6e-712b420ea228
Local pid:
pubs:114035
Deposit date:
2012-12-19

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