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A common gene pool for the Neisseria FetA antigen.

Abstract:

Meningococcal FetA is an iron-regulated, immunogenic outer membrane protein and vaccine component. The most diverse region of this protein is a previously defined variable region (VR) that has been shown to be immunodominant. In this analysis, a total of 275 Neisseria lactamica isolates, collected during studies of nasopharyngeal bacterial carriage in infants, were examined for the presence of a fetA gene. The fetA VR nucleotide sequence was determined for 217 of these isolates, with fetA app...

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Publication status:
Published

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Publisher copy:
10.1016/j.ijmm.2008.06.010

Authors


Bennett, JS More by this author
Thompson, EA More by this author
Jolley, KA More by this author
Maiden, MC More by this author
Journal:
International journal of medical microbiology : IJMM
Volume:
299
Issue:
2
Pages:
133-139
Publication date:
2009-02-05
DOI:
EISSN:
1618-0607
ISSN:
1438-4221
URN:
uuid:c8118ee7-3968-4f5b-a273-5f4bf8555737
Source identifiers:
210549
Local pid:
pubs:210549

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