Journal article
Recoding a cocaine-place memory engram to a neutral engram in the hippocampus
- Abstract:
- The hippocampus provides the brain's memory system with a subset of neurons holding a map-like representation of each environment experienced. We found in mice that optogenetic silencing those neurons active in an environment unmasked a subset of quiet neurons, enabling the emergence of an alternative map. When applied in a cocaine-paired environment, this intervention neutralized an otherwise long-lasting drug-place preference, showing that recoding a spatial memory engram can alleviate associated maladaptive behavior.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Neuroscience Journal website
- Volume:
- 19
- Issue:
- 2016
- Pages:
- 564-567
- Publication date:
- 2016-02-22
- Acceptance date:
- 2016-01-21
- DOI:
- EISSN:
-
1546-1726
- ISSN:
-
1097-6256
Item Description
- Language:
- English
- Pubs id:
-
pubs:605935
- UUID:
-
uuid:c804d444-6dc6-4afd-8b6d-153b4c800b9f
- Local pid:
- pubs:605935
- Source identifiers:
-
605935
- Deposit date:
- 2016-02-26
Terms of use
- Copyright holder:
- Trouche et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This is an accepted manuscript of a journal article published by Nature Publishing Group in Nature Neuroscience on 2016-02-22, available online: http://dx.doi.org/10.1038/nn.4250
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