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Recoding a cocaine-place memory engram to a neutral engram in the hippocampus

Abstract:
The hippocampus provides the brain's memory system with a subset of neurons holding a map-like representation of each environment experienced. We found in mice that optogenetic silencing those neurons active in an environment unmasked a subset of quiet neurons, enabling the emergence of an alternative map. When applied in a cocaine-paired environment, this intervention neutralized an otherwise long-lasting drug-place preference, showing that recoding a spatial memory engram can alleviate associated maladaptive behavior.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nn.4250

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BNDU
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BNDU
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BNDU
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BNDU
Role:
Author
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Grant:
MC_UU_12020/7
MC_UU_12024/3
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Neuroscience Journal website
Volume:
19
Issue:
2016
Pages:
564-567
Publication date:
2016-02-22
Acceptance date:
2016-01-21
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:c804d444-6dc6-4afd-8b6d-153b4c800b9f
Source identifiers:
605935
Local pid:
pubs:605935
Language:
English

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