Journal article icon

Journal article

Recoding a cocaine-place memory engram to a neutral engram in the hippocampus

Abstract:
The hippocampus provides the brain's memory system with a subset of neurons holding a map-like representation of each environment experienced. We found in mice that optogenetic silencing those neurons active in an environment unmasked a subset of quiet neurons, enabling the emergence of an alternative map. When applied in a cocaine-paired environment, this intervention neutralized an otherwise long-lasting drug-place preference, showing that recoding a spatial memory engram can alleviate associated maladaptive behavior.
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/nn.4250

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
BNDU
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
BNDU
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
BNDU
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
BNDU
Role:
Author
Expand authors...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Neuroscience Journal website
Volume:
19
Issue:
2016
Pages:
564-567
Publication date:
2016-02-22
Acceptance date:
2016-01-21
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
Source identifiers:
605935
Language:
English
Pubs id:
pubs:605935
UUID:
uuid:c804d444-6dc6-4afd-8b6d-153b4c800b9f
Local pid:
pubs:605935
Deposit date:
2016-02-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP