- Abstract:
-
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effec...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nm.1850
-
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- Journal:
- Nature medicine
- Volume:
- 14
- Issue:
- 8
- Pages:
- 819-821
- Publication date:
- 2008-08-05
- DOI:
- EISSN:
-
1546-170X
- ISSN:
-
1078-8956
- URN:
-
uuid:c7fe8d5e-f8fc-4bbe-a8cd-29f0abe1bd05
- Source identifiers:
-
34329
- Local pid:
- pubs:34329
- Copyright date:
- 2008
Journal article
Effective induction of high-titer antibodies by viral vector vaccines.
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