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Journal article

Effective induction of high-titer antibodies by viral vector vaccines.

Abstract:

Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effec...

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Publication status:
Published

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Publisher copy:
10.1038/nm.1850

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Journal:
Nature medicine
Volume:
14
Issue:
8
Pages:
819-821
Publication date:
2008-08-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:c7fe8d5e-f8fc-4bbe-a8cd-29f0abe1bd05
Source identifiers:
34329
Local pid:
pubs:34329

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