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Journal article

Recombinant polymorphic membrane protein D in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal Chlamydia trachomatis infection in mice.

Abstract:

The development of a chlamydial vaccine that elicits protective mucosal immunity is of paramount importance in combatting the global spread of sexually transmitted Chlamydia trachomatis (Ct) infections. While the identification and prioritization of chlamydial antigens is a crucial prerequisite for efficacious vaccine design, it is likely that novel adjuvant development and selection will also play a pivotal role in the translational potential of preclinical Ct vaccines. Although the molecula...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.vaccine.2016.06.081

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Brzozowski, AM More by this author
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Bill and Melinda Gates Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
34
Issue:
35
Pages:
4123-4131
Publication date:
2016-07-04
Acceptance date:
2016-06-29
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Pubs id:
pubs:718079
URN:
uri:c7fd328c-4006-4b3e-87a4-9c2d3e889df5
UUID:
uuid:c7fd328c-4006-4b3e-87a4-9c2d3e889df5
Local pid:
pubs:718079

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