The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease.

Journal article

Possession of the APOE-ε4 allele is the best established genetic risk factor for sporadic Alzheimer's disease (AD), while the ε2 allele may confer protection against the disease. Previous functional magnetic resonance imaging (fMRI) studies have shown an effect of APOE genotype on brain function, typically by comparing only ε4 carriers with noncarriers. Here we included a wide range of genotype groups to determine how closely the effects of APOE on brain function are related to differences in...

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Authors: Trachtenberg, A; Filippini, N; Cheeseman, J; Duff, E; Neville, M

• Publication status: Published
• Journal: Neurobiology of aging
• Volume: 33
• Issue: 3
• Pages: 618.e1-618.e13
• Publication date: 2012-03-01
• DOI: 10.1016/j.neurobiolaging.2010.11.011
• EISSN: 1558-1497
• ISSN: 0197-4580
• Language: English
• Keywords: Genotype; Middle Aged; Humans; Risk Factors; Alzheimer Disease; Apolipoproteins E; Female; Brain; Evoked Potentials; Adult; Male