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Firing of Hippocampal Neurogliaform cells induces suppression of synaptic inhibition

Abstract:

The hippocampus contains more than 21 types of inhibitory interneurons that express different proteins and innervate different sub-domains of pyramidal cells to regulate the spatiotemporal integration of excitatory postsynaptic potentials (EPSPs) and to define temporal windows for spiking. Neurogliaform cells (NGFCs), form synapses on the distal tufts of pyramidal cell apical dendrites alongside excitatory inputs from the entorhinal cortex. NGFCs express neuronal nitric oxide synthase (nNO...

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Institution:
University of Oxford
Oxford college:
St Edmund Hall
Department:
Medical Sciences Division - Pharmacology

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:c7f21808-73f9-41f4-bc99-55b2326ba725
Local pid:
ora:10124
Language:
English
Keywords:
Subjects:

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