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Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics.

Abstract:

Matrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated in numerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue inhibitors of metalloproteinases (TIMPs). This review highlights the structures and inhibition mecha...

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Publisher copy:
10.1186/ar573

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Arthritis research
Volume:
4 Suppl 3
Pages:
S51-S61
Publication date:
2002-01-01
DOI:
EISSN:
1465-9913
ISSN:
1465-9905
URN:
uuid:c7ef2baa-2d86-4cb1-988d-8d38e682a4f7
Source identifiers:
226907
Local pid:
pubs:226907

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