HIV-1-related pleural tuberculosis: elevated production of IFN-gamma, but failure of immunity to Mycobacterium tuberculosis.

Journal article

BACKGROUND: Pleural tuberculosis can resolve spontaneously, suggesting that the inflammatory process may represent a protective immune response. However, pleural tuberculosis is strongly associated with HIV infection. It has been suggested that cell-mediated immune responses may be reduced, and direct bacterial invasion may have a role in pathogenesis, in HIV-positive cases. To test this hypothesis, we compared production of the pro-inflammatory cytokines, interferon (IFN)-gamma and tumour ne...

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Authors: Hodsdon, W; Luzze, H; Hurst, T; Quigley, M; Kyosiimire, J

• Publication status: Published
• Journal: AIDS (London, England)
• Volume: 15
• Issue: 4
• Pages: 467-475
• Publication date: 2001-03-01
• DOI: 10.1097/00002030-200103090-00005
• EISSN: 1473-5571
• ISSN: 0269-9370
• Language: English
• Keywords: HIV-1; Adult; Interleukin-18; T-Lymphocyte Subsets; CD4-Positive T-Lymphocytes; Mycobacterium tuberculosis; Female; Male; HIV Seropositivity; HIV Infections; Humans; Tuberculosis, Pleural; HIV Seronegativity; CD8-Positive T-Lymphocytes; Interleukin-10; Tumor Necrosis Factor-alpha