Hyperubiquitination of proteins in dilated cardiomyopathy.

Journal article

Protein degradation by the ubiquitin-proteasome pathway plays an important role in a variety of fundamental cellular processes, including cell cycle regulation, transcription, antigen processing and muscle remodelling. Research into disorders associated with the ubiquitin-proteasome system has been mainly in the field of neurodegenerative diseases. It is however becoming increasingly apparent that defects in the system are responsible for a number of non-neurological pathologies. Based on ini...

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Authors: Weekes, J; Morrison, K; Mullen, A; Wait, R; Barton, P

• Publication status: Published
• Journal: Proteomics
• Volume: 3
• Issue: 2
• Pages: 208-216
• Publication date: 2003-02-01
• DOI: 10.1002/pmic.200390029
• EISSN: 1615-9861
• ISSN: 1615-9853
• Language: English
• Keywords: Ubiquitin; Cells, Cultured; Humans; Myocardium; Glutathione Transferase; RNA, Messenger; Immunohistochemistry; Thiolester Hydrolases; Blotting, Western; Reverse Transcriptase Polymerase Chain Reaction; Phenotype; Ubiquitin Thiolesterase; Electrophoresis, Gel, Two-Dimensional; Myocardial Ischemia; Cardiomyopathy, Dilated