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Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.

Abstract:

Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous stud...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0014741

Authors


More from this funder
Name:
Medical Research Council
Grant:
70959
More from this funder
Name:
Wellcome Trust
Grant:
084535
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
6
Issue:
3
Pages:
e14741
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:c7ded038-c1ae-4015-9c3d-96324c756138
Local pid:
pubs:124587
Source identifiers:
124587
Deposit date:
2012-12-19

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