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The molecular basis of filamin binding to integrins and competition with talin.

Abstract:

The ability of adhesion receptors to transmit biochemical signals and mechanical force across cell membranes depends on interactions with the actin cytoskeleton. Filamins are large, actin-crosslinking proteins that connect multiple transmembrane and signaling proteins to the cytoskeleton. Here, we describe the high-resolution structure of an interface between filamin A and an integrin adhesion receptor. When bound, the integrin beta cytoplasmic tail forms an extended beta strand that interact...

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Journal:
Molecular cell More from this journal
Volume:
21
Issue:
3
Pages:
337-347
Publication date:
2006-02-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765

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