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The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.

Abstract:

Ras activation as a consequence of antigen receptor (T-cell receptor; TCR) engagement on T lymphocytes is required for T-cell development, selection and function. Lymphocyte function-associated antigen-1 (LFA-1) mediates lymphocyte adhesion, stabilization of the immune synapse and bidirectional signalling. Using a fluorescent biosensor we found that TCR activation with or without costimulation of CD28 led to activation of Ras only on the Golgi apparatus, whereas costimulation with LFA-1 induc...

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Publisher copy:
10.1038/ncb1592

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Journal:
Nature cell biology
Volume:
9
Issue:
6
Pages:
713-719
Publication date:
2007-06-01
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
Source identifiers:
482598

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