The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.

Journal article

Ras activation as a consequence of antigen receptor (T-cell receptor; TCR) engagement on T lymphocytes is required for T-cell development, selection and function. Lymphocyte function-associated antigen-1 (LFA-1) mediates lymphocyte adhesion, stabilization of the immune synapse and bidirectional signalling. Using a fluorescent biosensor we found that TCR activation with or without costimulation of CD28 led to activation of Ras only on the Golgi apparatus, whereas costimulation with LFA-1 induc...

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Authors: Mor, A; Campi, G; Du, G; Zheng, Y; Foster, D

• Journal: Nature cell biology
• Volume: 9
• Issue: 6
• Pages: 713-719
• Publication date: 2007-06-01
• DOI: 10.1038/ncb1592
• EISSN: 1476-4679
• ISSN: 1465-7392
• Language: English
• Keywords: T-Lymphocytes; Receptors, Antigen, T-Cell; Mice, Knockout; Type C Phospholipases; Signal Transduction; Guanine Nucleotide Exchange Factors; Cell Communication; ras Proteins; Mice; Mice, Inbred C57BL; Enzyme Activation; DNA-Binding Proteins; Humans; Diglycerides; Animals; Jurkat Cells; Phospholipase D; Cell Membrane; Golgi Apparatus; Antigens, CD28; Lymphocyte Function-Associated Antigen-1