Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers.

Journal article

Abstract:: The demonstration that dendritic cell (DC)-derived exosomes can be exploited for targeted RNAi delivery to the brain after systemic injection provides the first proof-of-concept for the potential of these naturally occurring vesicles as vehicles of drug delivery. As well as being amenable to existing in vivo targeting strategies already in use for viruses and liposomes, this novel approach offers the added advantages of in vivo safety and low immunogenicity. Fulfilment of the potential of exo...
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Role:

Author

Institution:

University of Oxford

Division:

MSD

Department:

Physiology Anatomy & Genetics

Role:

Author

Journal:: BioEssays : news and reviews in molecular, cellular and developmental biology More from this journal
Volume:: 33
Issue:: 10
Pages:: 737-741
Publication date:: 2011-10-01
DOI:: 10.1002/bies.201100076
EISSN:: 1521-1878
ISSN:: 0265-9247

Language:: English
Keywords:: Drug Delivery Systems

Rabies virus

Dendritic Cells

Pharmaceutical Preparations

Blood-Brain Barrier

Drug Carriers

RNA Interference

Glycoproteins

Humans

Exosomes

Viral Proteins

Nanotechnology
Pubs id:: pubs:179908
UUID:: uuid:c7bf2e47-bef8-4a2b-ae49-fe43a788864e
Local pid:: pubs:179908
Source identifiers:: 179908
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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