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Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial

Abstract:
Background: Although WHO recommends viral load (VL) monitoring on antiretroviral therapy (ART), availability in low-income countries remains limited. We investigated long-term VL and resistance in HIV-infected children managed without real-time VL monitoring. Methods and Findings: In the ARROW factorial trial, 1206 children initiating ART in Uganda and Zimbabwe between 15 March 2007 and 18 November 2008, aged median 6 years old, with median CD4% 12%, were ra... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1002432

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Grant:
G0300400 (AJP, VM, PM, MB-D, NK, DMG, ASW)
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
14
Issue:
11
Pages:
Article: e1002432
Publication date:
2017-11-14
Acceptance date:
2017-10-09
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:734932
URN:
uri:c7bed3e8-8a12-4569-8a1e-125216733f50
UUID:
uuid:c7bed3e8-8a12-4569-8a1e-125216733f50
Local pid:
pubs:734932
Paper number:
11

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