- Abstract:
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Background: Although WHO recommends viral load (VL) monitoring on antiretroviral therapy (ART), availability in low-income countries remains limited. We investigated long-term VL and resistance in HIV-infected children managed without real-time VL monitoring. Methods and Findings: In the ARROW factorial trial, 1206 children initiating ART in Uganda and Zimbabwe between 15 March 2007 and 18 November 2008, aged median 6 years old, with median CD4% 12%, were ra... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.9MB)
-
- Publisher copy:
- 10.1371/journal.pmed.1002432
-
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- Grant:
- MRC/DFID Concordat agreement
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Medicine Journal website
- Volume:
- 14
- Issue:
- 11
- Pages:
- Article: e1002432
- Publication date:
- 2017-11-14
- Acceptance date:
- 2017-10-09
- DOI:
- EISSN:
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1549-1676
- ISSN:
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1549-1277
- Pubs id:
-
pubs:734932
- URN:
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uri:c7bed3e8-8a12-4569-8a1e-125216733f50
- UUID:
-
uuid:c7bed3e8-8a12-4569-8a1e-125216733f50
- Local pid:
- pubs:734932
- Paper number:
- 11
- Copyright holder:
- Szubert et al.
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Szubert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial
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