2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo.

Journal article

The mammalian retina contains directly photosensitive retinal ganglion cells (RGCs), which use the photopigment melanopsin. The generation of mice lacking melanopsin has been invaluable in elucidating the function of these cells. These animals display deficiencies in circadian photoentrainment, the pupil light reflex, and the circadian regulation of the cone pathway. Interpreting the results from such gene knock-out models is always complicated by neuronal plasticity and the potential for res...

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Authors: Sekaran, S; Lall, G; Ralphs, K; Wolstenholme, A; Lucas, R

• Publication status: Published
• Journal: Journal of neuroscience : the official journal of the Society for Neuroscience
• Volume: 27
• Issue: 15
• Pages: 3981-3986
• Publication date: 2007-04-01
• DOI: 10.1523/jneurosci.4716-06.2007
• EISSN: 1529-2401
• ISSN: 0270-6474
• Language: English
• Keywords: Animals; Retinal Ganglion Cells; TRPC Cation Channels; Cell Line; Neural Inhibition; Mice, Inbred C3H; Boron Compounds; Mice; Photic Stimulation; Action Potentials; Mice, Transgenic