Empiric deworming to delay HIV disease progression in adults with HIV who are ineligible for initiation of antiretroviral treatment (the HEAT study): a multi-site, randomised trial.

Journal article

BACKGROUND: Co-infection with HIV and helminths is common in sub-Saharan Africa and findings from previous studies have suggested that anthelmintic treatment might delay immunosuppression in people with HIV. We aimed to assess the efficacy of empiric deworming of adults with HIV in delaying HIV disease progression. METHODS: In this non-blinded randomised trial, we enrolled adults (aged ≥18 years) with HIV who did not meet criteria for the initiation of antiretroviral treatment from three site...

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Authors: Walson, J; Singa, B; Sangaré, L; Naulikha, J; Piper, B

• Publication status: Published
• Journal: Lancet. Infectious diseases
• Volume: 12
• Issue: 12
• Pages: 925-932
• Publication date: 2012-12-01
• DOI: 10.1016/s1473-3099(12)70207-4
• EISSN: 1474-4457
• ISSN: 1473-3099
• Language: English
• Keywords: Helminths; Disease Progression; Male; Proportional Hazards Models; Kaplan-Meier Estimate; Praziquantel; Albendazole; RNA, Viral; HIV-1; CD4 Lymphocyte Count; Anthelmintics; HIV Infections; Kenya; Female; Humans; Adult; Helminthiasis; Animals