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Review: neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy.

Abstract:

Amid the great diversity of neurodegenerative conditions, there is a growing body of evidence that non-somatic (that is, synaptic and distal axonal) compartments of neurones are early and important subcellular sites of pathological change. In this review we discuss experimental data from human patients, animal models and in vitro systems showing that neuromuscular synapses are targeted in different forms of motor neurone disease (MND), including amyotrophic lateral sclerosis and spinal muscul...

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Neuropathology and applied neurobiology
Volume:
36
Issue:
2
Pages:
133-156
Publication date:
2010-04-01
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
Source identifiers:
245228
Language:
English
Keywords:
Pubs id:
pubs:245228
UUID:
uuid:c7bb82ea-918e-477a-bbbb-865fc90af58a
Local pid:
pubs:245228
Deposit date:
2012-12-19

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