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Review: neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy.

Abstract:

Amid the great diversity of neurodegenerative conditions, there is a growing body of evidence that non-somatic (that is, synaptic and distal axonal) compartments of neurones are early and important subcellular sites of pathological change. In this review we discuss experimental data from human patients, animal models and in vitro systems showing that neuromuscular synapses are targeted in different forms of motor neurone disease (MND), including amyotrophic lateral sclerosis and spinal muscul...

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Authors


Murray, LM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Gillingwater, TH More by this author
Journal:
Neuropathology and applied neurobiology
Volume:
36
Issue:
2
Pages:
133-156
Publication date:
2010-04-05
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
URN:
uuid:c7bb82ea-918e-477a-bbbb-865fc90af58a
Source identifiers:
245228
Local pid:
pubs:245228

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