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Journal article

Coating of adeno-associated virus with reactive polymers can ablate virus tropism, enable retargeting and provide resistance to neutralising antisera.

Abstract:

BACKGROUND: Copolymers based on poly-[N-(2-hydroxypropyl) methacrylamide] (HPMA) have been used previously to enable targeted delivery of adenovirus. Here we demonstrate polymer-coating techniques can also be used to modify and retarget adeno-associated virus (AAV) types 5 and 8. METHODS: Three strategies for modifying transductional targeting of AAV were employed. The first involved direct reaction of AAV5 or AAV8 with amino-reactive HPMA copolymer. The second approach used carbodiimide (EDC...

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Publication status:
Published

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Publisher copy:
10.1002/jgm.1161

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
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Journal:
journal of gene medicine
Volume:
10
Issue:
4
Pages:
400-411
Publication date:
2008-04-01
DOI:
EISSN:
1521-2254
ISSN:
1099-498X
Source identifiers:
178618
Language:
English
Keywords:
Pubs id:
pubs:178618
UUID:
uuid:c7b325cd-d029-4f53-824d-7ee867ac9404
Local pid:
pubs:178618
Deposit date:
2012-12-19

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