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An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia

Abstract:

BACKGROUND:
The artemisinin-based combination treatment (ACT) of dihydroartemisinin (DHA) and piperaquine (PQP) is a promising novel anti-malarial drug effective against multi-drug resistant falciparum malaria. The aim of this study was to show non-inferiority of DHA/PQP vs. artesunate-mefloquine (AS+MQ) in Asia.
METHODS AND FINDINGS:
This was an open-label, randomised, non-inferiority, 63-day follow-up study conducted in Thailand, Laos and India. Patients aged 3 months to 65 ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0011880

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Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
7
Pages:
e11880
Publication date:
2010-07-30
DOI:
EISSN:
1932-6203
Pubs id:
pubs:67531
URN:
uri:c7b079a6-0569-4254-9230-b38e0210d6e4
UUID:
uuid:c7b079a6-0569-4254-9230-b38e0210d6e4
Local pid:
pubs:67531
Paper number:
7

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