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Macrophage Cell-Cell Interactions Promoting HIV-1 Infection

Abstract:

Many pathogens infect macrophages as part of their intracellular life cycle. This is particularly true for viruses, of which HIV-1 is one of the best studied. HIV-1 infection of macrophages has important consequences for viral persistence and pathogenesis, but the mechanisms of macrophage infection remain to be fully elucidated. Despite expressing viral entry receptors, macrophages are inefficiently infected by cell-free HIV-1 virions, whereas direct cell-cell spread is more efficient. Differ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/v12050492

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
MDPI Publisher's website
Journal:
Viruses Journal website
Volume:
12
Issue:
5
Article number:
492
Publication date:
2020-04-28
Acceptance date:
2020-04-27
DOI:
EISSN:
1999-4915
Language:
English
Keywords:
Pubs id:
1102315
Local pid:
pubs:1102315
Deposit date:
2020-04-29

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