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Journal article

Notch receptor-ligand binding and activation: insights from molecular studies.

Abstract:

The Notch receptor is part of a core signalling pathway which is highly conserved in all metazoan species. It is required for various cell fate decisions at multiple stages of development and in the adult organism, with dysregulation of the pathway associated with genetic and acquired diseases including cancer. Although cellular and in vivo studies have provided considerable insight into the downstream consequences of Notch signalling, relatively little is known about the molecular basis of t...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Seminars in cell and developmental biology
Volume:
23
Issue:
4
Pages:
421-428
Publication date:
2012-06-01
DOI:
EISSN:
1096-3634
ISSN:
1084-9521
Source identifiers:
254298
Language:
English
Keywords:
Pubs id:
pubs:254298
UUID:
uuid:c7a9fd49-b03f-4a4d-9a82-d34c9a019b05
Local pid:
pubs:254298
Deposit date:
2012-12-19

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