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Bias of selection on human copy-number variants.

Abstract:

Although large-scale copy-number variation is an important contributor to conspecific genomic diversity, whether these variants frequently contribute to human phenotype differences remains unknown. If they have few functional consequences, then copy-number variants (CNVs) might be expected both to be distributed uniformly throughout the human genome and to encode genes that are characteristic of the genome as a whole. We find that human CNVs are significantly overrepresented close to telomere...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
PLoS genetics More from this journal
Volume:
2
Issue:
2
Pages:
e20
Publication date:
2006-02-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
Pubs id:
pubs:237082
UUID:
uuid:c7a2392a-d165-4400-ad94-7f1b28bdfaa3
Local pid:
pubs:237082
Source identifiers:
237082
Deposit date:
2012-12-19

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