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Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells

Abstract:

Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes in vivo will contribute to the clinical exploitation of Foxp3+ Treg. Here, we show that both in vitro and in vivo generated antigen-specific Foxp3+ Treg can acquir...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2016.00124

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Medical Research Council More from this funder
More from this funder
Funding agency for:
Hilbrands, R
Grant:
Long-term fellowship (ALTF309-2011
European Research Council More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Publication date:
2016-04-11
Acceptance date:
2016-03-21
DOI:
ISSN:
1664-3224
Source identifiers:
611601
Keywords:
Pubs id:
pubs:611601
UUID:
uuid:c7a12c9d-b0c4-4025-8f36-e797af22deee
Local pid:
pubs:611601
Deposit date:
2016-03-24

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