Journal article
Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays
- Abstract:
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In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 577.8KB)
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- Publisher copy:
- 10.1128/AAC.02169-16
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Authors
Funding
+ National Institute for Health Research
More from this funder
Funding agency for:
Peto, T
Grant:
T5-358
+ National Institute for Health Research
More from this funder
Funding agency for:
Crook, D
Grant:
T5-358
Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial Agents and Chemotherapy Journal website
- Volume:
- 61
- Issue:
- 4
- Pages:
- e02169-16
- Publication date:
- 2017-04-01
- Acceptance date:
- 2017-01-16
- DOI:
- EISSN:
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1098-6596
- ISSN:
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0066-4804
- Source identifiers:
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679534
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:679534
- UUID:
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uuid:c7a0d7a0-3872-476b-8c14-99bf8065f7a7
- Local pid:
- pubs:679534
- Deposit date:
- 2017-04-26
Terms of use
- Copyright holder:
- Ajileye et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 Ajileye et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Licence:
- CC Attribution (CC BY)
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