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Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays

Abstract:

In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/AAC.02169-16

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
Peto, T
Grant:
T5-358
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Funding agency for:
Peto, T
Grant:
T5-358
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Funding agency for:
Crook, D
Grant:
T5-358
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Funding agency for:
Crook, D
Grant:
T5-358
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
61
Issue:
4
Pages:
e02169-16
Publication date:
2017-04-01
Acceptance date:
2017-01-16
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Source identifiers:
679534
Language:
English
Keywords:
Pubs id:
pubs:679534
UUID:
uuid:c7a0d7a0-3872-476b-8c14-99bf8065f7a7
Local pid:
pubs:679534
Deposit date:
2017-04-26

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