Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers.

Journal article

The virulence of the malaria parasite Plasmodium falciparum is due, in part, to its ability to cytoadhere in deep vascular beds. Our inability to quantify the load of sequestered parasites hampers our understanding of the pathophysiological mechanisms involved in disease progression and complicates diagnosis. In this study we evaluate potential biochemical markers of sequestered load by comparing them with estimates of the sequestered load from a statistical model fitted to longitudinal patte...

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Authors: Ochola, L; Marsh, K; Lowe, B; Gal, S; Pluschke, G

• Publication status: Published
• Journal: Parasitology
• Volume: 131
• Issue: Pt 4
• Pages: 449-458
• Publication date: 2005-10-01
• DOI: 10.1017/s0031182005008085
• EISSN: 1469-8161
• ISSN: 0031-1820
• Language: English
• Keywords: Models, Biological; Humans; Statistics, Nonparametric; Animals; DNA, Protozoan; Population Density; Biological Markers; Erythrocytes; Malaria, Falciparum; Plasmodium falciparum; Parasitemia; Antimalarials; Hematocrit; Child, Preschool; Receptors, Tumor Necrosis Factor, Type II; Quinine; Female; Male; Infant