- Abstract:
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The in situ oxygen partial pressure in normal and tumor tissues is in the range of a few percent. Therefore, when studying cell growth in 3D culture systems, it is essential to consider how the physiological oxygen concentration, rather than the one in the ambient air, influences the proliferation parameters. Here, we investigated the effect of reducing oxygen partial pressure from 21% to 5% on cell proliferation rate and regionalization in a 3D tumor spheroid model. We found that 5% oxygen c...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 2.1MB)
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- Publisher copy:
- 10.1371/journal.pone.0161239
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS One Journal website
- Publication date:
- 2016-08-30
- Acceptance date:
- 2016-08-02
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Pubs id:
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pubs:641523
- URN:
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uri:c792eca4-2158-4003-b947-caf89c5c8d0d
- UUID:
-
uuid:c792eca4-2158-4003-b947-caf89c5c8d0d
- Local pid:
- pubs:641523
- Copyright holder:
- Gomes et al.
- Copyright date:
- 2016
- Notes:
- © 2016 Gomes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Journal article
Oxygen Partial Pressure Is a Rate-Limiting Parameter for Cell Proliferation in 3D Spheroids Grown in Physioxic Culture Condition
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