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Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding

Abstract:

A causative role for single nucleotide polymorphisms (SNPs) in many genetic disorders has become evident through numerous genome-wide association studies. However, identification of these common causal variants and the molecular mechanisms underlying these associations remains a major challenge. Differential transcription factor binding at a SNP resulting in altered gene expression is one possible mechanism. Here we apply PWAS ("proteome-wide analysis of SNPs"), a methodology based on quantit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Genetics More from this journal
Volume:
8
Issue:
9
Pages:
e1002982
Publication date:
2012-09-27
Acceptance date:
2012-08-09
DOI:
EISSN:
1553-7404
ISSN:
1553-7390

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