Journal article
Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding
- Abstract:
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A causative role for single nucleotide polymorphisms (SNPs) in many genetic disorders has become evident through numerous genome-wide association studies. However, identification of these common causal variants and the molecular mechanisms underlying these associations remains a major challenge. Differential transcription factor binding at a SNP resulting in altered gene expression is one possible mechanism. Here we apply PWAS ("proteome-wide analysis of SNPs"), a methodology based on quantit...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 1018.0KB)
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- Publisher copy:
- 10.1371/journal.pgen.1002982
Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 8
- Issue:
- 9
- Pages:
- e1002982
- Publication date:
- 2012-09-27
- Acceptance date:
- 2012-08-09
- DOI:
- EISSN:
-
1553-7404
- ISSN:
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1553-7390
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:c788222f-c2b9-4f42-8b24-9c1a79259cef
- Local pid:
- pubs:445335
- Source identifiers:
-
445335
- Deposit date:
- 2014-02-08
Terms of use
- Copyright holder:
- Butter et al
- Copyright date:
- 2012
- Notes:
- © Butter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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