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Journal article

Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis.

Abstract:

Sensitive and reproducible methods are needed to measure the impact on the host following experimental challenge with Mycobacterium tuberculosis, in order to determine the degree of protection conferred by new vaccines. Here we compare how well different clinical and post-mortem measures of disease burden predict the response by the host to increasing doses of M. tuberculosis in rhesus and cynomolgus macaques. The total lung and lesion volume was quantified from magnetic resonance imaging (MR...

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Publication status:
Published

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Publisher copy:
10.1016/j.tube.2009.09.002

Authors


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Journal:
Tuberculosis (Edinburgh, Scotland)
Volume:
89
Issue:
6
Pages:
405-416
Publication date:
2009-11-01
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
Source identifiers:
324217
Language:
English
Keywords:
Pubs id:
pubs:324217
UUID:
uuid:c7852d0c-2e6c-4b97-a1ec-6b44b23a4f17
Local pid:
pubs:324217
Deposit date:
2013-11-16

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