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A detailed in vivo analysis of the retinal nerve fibre layer in choroideremia

Abstract:

Purpose

Choroideremia is a currently incurable X‐linked recessive retinal degeneration that leads to blindness. Gene therapy approaches to date target the outer retinal layers. However, the choroideremia (CHM) gene is expressed in all retinal layers, and a previous study on a small cohort of choroideremia patients suggested possible thinning of the retinal nerve fibre layer (RNFL). The purpose of the study was to examine the RNFL in detail using advanced imaging techni... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/aos.13973

Authors


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Role:
Author
ORCID:
0000-0003-2852-6912
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-0065-9131
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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-9878-4621
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Role:
Author
ORCID:
0000-0002-3096-4682
Publisher:
Wiley Publisher's website
Host title:
Acta Ophthalmologica
Journal:
Acta Ophthalmologica Journal website
Volume:
97
Issue:
4
Pages:
e589-e600
Publication date:
2018-12-21
Acceptance date:
2018-10-18
Event location:
England
DOI:
EISSN:
1755-3768
ISSN:
1755-375X
Pmid:
30575280
Keywords:
Pubs id:
pubs:926229
UUID:
uuid:c77dd94f-de7c-407f-aa03-6571298a7368
Local pid:
pubs:926229
Source identifiers:
926229
Deposit date:
2019-05-12

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